Very good news regarding the Coronavirus
A lot of progress has taken place in understanding the coranavirus.The genes have been sequenced and proteins have been made.
Indeed, one of those proteins is a "spike" protein that the virus uses to attach
to a host cell. It's sort of like an anchor that initiates further progress in the
infection process.
After the virus attached to the cell, the membranes of the cell and the virus then fuse,
enabling the RNA of the virus to enter the cell and direct new virus production.
Well, genes for this spike protein itself have been isolated and incorporated into cells.
These cells were then used to make lots of this spike protein.
Subsequently, this protein has been 3D mapped and now it has been sent to many
research teams to both produce drugs for treatment and to use as antigens to make vaccines.
Thus within a month or two, vaccines will possibly become made and tested for effectiveness.
The bottom line, is that progress is rapidly being undertaken.
There may actually be something good to come out of this. The common cold is caused by a virus
in the coronavirus family. Imagine if one of the vaccines against the new virus also works to
prevent the common cold. It is possible. It would be a nice positive side effect.
I can hear the potential commercials now.
Here's a recent article from LiveScience;
In response to:
Coronavirus 'spike' protein just mapped, leading way to vaccine
By Yasemin Saplakoglu - Staff Writer 2 days ago
Researchers worldwide are racing to develop potential vaccines and drugs to fight the new coronavirus, called SARS-Cov-2. Now, a group of researchers has figured out the molecular structure of a key protein that the coronavirus uses to invade human cells, potentially opening the door to the development of a vaccine, according to new findings.
Previous research revealed that coronaviruses invade cells through so-called "spike" proteins, but those proteins take on different shapes in different coronaviruses. Figuring out the shape of the spike protein in SARS-Cov-2 is the key to figuring out how to target the virus, said Jason McLellan, senior author of the study and an associate professor of molecular biosciences at the University of Texas at Austin.
All about COVID-19.
Though the coronavirus uses many different proteins to replicate and invade cells, the spike protein is the major surface protein that it uses to bind to a receptor — another protein that acts like a doorway into a human cell. After the spike protein binds to the human cell receptor, the viral membrane fuses with the human cell membrane, allowing the genome of the virus to enter human cells and begin infection. So "if you can prevent attachment and fusion, you will prevent entry," McLellan told Live Science. But to target this protein, you need to know what it looks like.
Earlier this month, researchers published the genome of SARS-Cov-2. Using that genome, McLellan and his team, in collaboration with the National Institutes of Health (NIH), identified the specific genes that code for the spike protein. They then sent that gene information to a company that created the genes and sent them back. The group then injected those genes into mammalian cells in a lab dish and those cells produced the spike proteins.
Next, using a very detailed microscopy technique called cryogenic electron microscopy, the group created a 3D "map," or "blueprint," of the spike proteins. The blueprint revealed the structure of the molecule, mapping the location of each of its atoms in space.
"It's impressive that these researchers were able to get the structure so quickly," said Aubree Gordon, an associate professor of epidemiology at the University of Michigan who was not a part of the study. "It's a very important step forward and may help in the development of a vaccine against SARS-COV-2."...
Coronavirus 'spike' protein just mapped, leading way to vaccine
By Yasemin Saplakoglu - Staff Writer 2 days ago
Researchers worldwide are racing to develop potential vaccines and drugs to fight the new coronavirus, called SARS-Cov-2. Now, a group of researchers has figured out the molecular structure of a key protein that the coronavirus uses to invade human cells, potentially opening the door to the development of a vaccine, according to new findings.
Previous research revealed that coronaviruses invade cells through so-called "spike" proteins, but those proteins take on different shapes in different coronaviruses. Figuring out the shape of the spike protein in SARS-Cov-2 is the key to figuring out how to target the virus, said Jason McLellan, senior author of the study and an associate professor of molecular biosciences at the University of Texas at Austin.
All about COVID-19.
Though the coronavirus uses many different proteins to replicate and invade cells, the spike protein is the major surface protein that it uses to bind to a receptor — another protein that acts like a doorway into a human cell. After the spike protein binds to the human cell receptor, the viral membrane fuses with the human cell membrane, allowing the genome of the virus to enter human cells and begin infection. So "if you can prevent attachment and fusion, you will prevent entry," McLellan told Live Science. But to target this protein, you need to know what it looks like.
Earlier this month, researchers published the genome of SARS-Cov-2. Using that genome, McLellan and his team, in collaboration with the National Institutes of Health (NIH), identified the specific genes that code for the spike protein. They then sent that gene information to a company that created the genes and sent them back. The group then injected those genes into mammalian cells in a lab dish and those cells produced the spike proteins.
Next, using a very detailed microscopy technique called cryogenic electron microscopy, the group created a 3D "map," or "blueprint," of the spike proteins. The blueprint revealed the structure of the molecule, mapping the location of each of its atoms in space.
"It's impressive that these researchers were able to get the structure so quickly," said Aubree Gordon, an associate professor of epidemiology at the University of Michigan who was not a part of the study. "It's a very important step forward and may help in the development of a vaccine against SARS-COV-2."...
Comments (48)
I'm no microbiologist, but a Queensland team, are looking at an mRNA, based potential vaccine, which, when injected, enters the body's cells, causing them to produce a protein, which "clogs up" the receptors on the Covid virus, rendering it non-infective.
Clinical trials have already begun, I believe.
A vaccine pre-initiates an immunological response.
What you describe is a step away from genetic engineering. There would (or should) be much longer
range animal trials to determine what else those newly induced proteins might muck up, besides the viral attachment sites. Antibodies are highly specific, and thus, much safer and thus, have far less potential side effects. I'm guessing, that there would be more ethical resistance from the public too, especially if a reverse transcritase ends up making gene copies of that RNA.
Biotech startup Moderna is developing an RNA-based vaccine candidate called mRNA-1273 through a program funded by CEPI. Last month, the company shipped a batch of the vaccine to the National Institute of Allergy and Infectious Diseases (NIAID), a division under the National Institutes of Health. Clinical trials are expected to start next week and conclude on June 1 next year.
Personally I believe that false hope is worse than no hope, but there is some hope. I too hope that there shall be a vaccine for this virus and quickly too. But I read multiple sources, scientific academic and media, and I am not convinced something will happen in time for this pandemic. False hope generates bad practice - look at your spring break for example. Lockdowns in the UK and US are late, decisions influenced by false hope. It's good to see many positive stories of some very clever people working round the clock to beat this. I just question the timing. Like the one you mentioned is over a year away.
I believe that false hope is worse than no hope
"It ain't gonna happen anytime soon!"
Prove me wrong and the world will be a better place.
Maybe a vaccine after a while.
They need to stop the grinding halt they've caused and let things start getting back more to normal.
Since we don't have a proven drug in hand, and most drugs have side effects, however,
I would still not throw all caution to the wind. Even literally, that could be an undoing.
It's still best to proceed with caution and avoid contact with humans and surfaces that humans have contacted. Plus, make sure you thoroughly wash your hands before touching your nose, mouth, or eyes.