destiny will hit you

A famous local proverb"misfortune persues untill the grave".
In the above perspective fortunates enjoy living with their good luck and unfortunates are always sorrowing for and mourning their bad luck.
Did you believe in destiny personally I do.
Can someone defeat destiny by constant struggle and can erase the writings of destiny through his intellectual abilities.did The great and successful people create good luck for themselves or they were destined to it.