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In a race against a faster-spreading variant of the virus, ministers have pinned their hopes of easing a third national lockdown on protecting the most vulnerable groups by spring.
How is the rollout going?
The UK vaccine programme has entered the second part of its first phase after everyone in the first four priority groups - those aged 70 and over, care home residents, healthcare workers and people required to shield - were offered a jab by mid-February.
The rollout is now being expanded to include those aged 60 and above and those with underlying health conditions. The rest of the over-50s will follow, with the government aiming to offer everyone in priority groups five to nine a jab by 15 April.
These groups account for 88% of deaths so far.
More than 20 million people so far have had a first vaccine dose - equivalent to more than one in three adults in the UK. Nearly 800,000 have had a second.
The number of first doses administered each day had been steadily climbing since December - reaching more than 400,000 a day mid-February.
However, the current seven-day average for first doses is about 358,000 doses a day.
Prof Jonathan Van-Tam, England's deputy chief medical officer, acknowledged there were "supply fluctuations" for the vaccines and said it could take "a few months" for manufacturers to get into a steady routine for production.