Jwilly454545: Big but scary

No Photo ManNo photo
Like Me
Favorite Me

My Details

More About Me

The structure of Tramadol consists of three notable functional groups: a tertiary alcohol, a tertiary amine, and an ether connected to a benzene ring. Only one of the functional groups, the tertiary amine, is an ionizable functional group a part of the molecule, where the tertiary amine The pKa of the protonated tertiary amine group is 10.8 while the pKa of tramadol entirely is 9.41. The pKa’s are presented in Figure 1 below.

More about my Match

Another mechanism is described in Figure 7 below, where a patented synthesis of trans-tramadol chloride is displayed. The starting material for this reaction can be just trans-tramadol, or a mixture of trans-tramadol and cis-tramadol. Either way, cis-tramadol will be eliminated from the reaction due to the inclusion of 1,4-dioxane before purification.9 The purpose of eliminating cis-tramadol during the reaction is because the actual tablet form of tramadol exists as a racemic mixture of both the trans stereoisomers of the molecule ((R,R)-tramadol and (S,S)-tramadol), so any inclusion of the cis steriosomers before tablet synthesis is not required.9 The synthesis of trans tramadol hydrochloride is important because it changes the molecule to a salt that can be orally ingested.


My job resides on top of a cliff.

Back to Top
ConnectingSingles does not do background checks and does not manually screen every profile.
To Report Abuse: If this profile or the behavior of the member is inappropriate, click here to Report Abuse »