Insulin for weight-loss

I'd never heard of this before - insulin for non-diabetics, as a way to lose weight. A man in his early 70s that I know has recently started it, because his overweight daughter did. I looked it up, and seems there's quite a trend, mainly in the US. They are not in the US but their doctor is providing the stuff and monitoring quantities and, presumably, their health.

Changing the body's chemical make-up - AND knowing that diabetics struggle to rid themselves of stored bellyfat when they start on insulin - is surely not a great idea, but father and daughter are both very happy so far with reduced appetite and steady weightloss, don't mind the occasional attack of biliousness. Both are pretty large.

Anyone know more pros and cons - literally asking for a friend, since his wife (a naturally skinny wench who therefore Doesn't Understand How Hard It Is To Lose Weight) is absolutely appalled.
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Comments (32)

Yep can be done.
Some people actually eat tape worms too.
In the early 80's some rich woman died/was murdered. She was using Insulin for weight loss and someone overdosed her.
I know there was a trial but can't recall the details.
Body Builders take Lisinipril a Blood pressure med for the extra muscle building use.
Lisinipril is made from snake venom.


teddybear
Ozempic helps people lose weight

This all the rage in Australia & yes it definietly works

The unexpected increase in demand for the drug for weight loss has caused a worldwide shortage. Producing the drug — delivered as a weekly self-administered injection — involves a unique manufacturing set-up, so it will take some time to re-establish a global supply. It's expected back in Australia at the end of March 2023

Semaglutide (in the form of Ozempic) is an effective medication in managing type 2 diabetes — and the shortage has left some people with diabetes struggling to find pharmacies with their treatment in stock. For many people with diabetes, Ozempic has controlled their blood sugar (and often also helped them lose weight) more effectively than other medications.

Due to the shortage of Ozempic, Australian GPs have been advised against prescribing it to treat obesity.

However, semaglutide in the form of Wegovy is designed specifically for weight loss. United States and Australian regulators have recently approved Wegovy for that purpose, though it hasn't been available for use in Australia to date.

When the shortage is resolved and semaglutide is once again available in Australia for those with diabetes, it's unclear who will be able to access it for weight loss. Patients and doctors are also asking how much they will pay, and what role it will play in managing obesity.

How does it work?
Semaglutide works in several ways, including increasing feelings of fullness by acting on appetite centres in the brain and slowing stomach emptying.

It affects the secretion of insulin and glucagon, which is why it is so effective in diabetes.

It also reduces the risk of heart attacks and strokes. Other weight-loss drugs in the past have reduced weight but increased the risk of dying from a heart attack, which made them overall too dangerous.

Semaglutide is causing a social media frenzy. So what is it?
A social media frenzy has drained stocks of a drug for treating diabetes and obesity, leaving those who need it waiting until next year for resupply.

A close-up of a blue injector pen.
Read more
Studies show semaglutide helps 66-84 per cent of people who use the drug to lose weight, making it more effective than other drugs on the market

After two years, patients using it still benefit by not regaining their lost weight — but only if they are still taking the drug.

Disappointingly, once stopped, patients notice a gradual regain of up to two-thirds of the weight they lost. So essentially, semaglutide works only while taking it — it "manages" but does not "cure".

Semaglutide is meant to be an add-on, not a replacement, for exercise and a healthy diet.

Research on the medication has always been done in been done in conjunction with a healthy diet and exercise, as that is considered best practice. So we don't know what happens if you just take the medication without also starting or maintaining a healthy lifestyle. We do know exercise is key to keeping weight off over time.
Yup I heard that of the opera singer Maria Callas. No idea if it is true or urban myth. Some people let polyps go untreated because there's such a big weight loss. dunno

The question should really have been not whether it works in the short-term, but are there longer-term problems greater than being obese?
Ok I'm cherrypicking questions from the info, and thanks for that - so there is the likelihood of having to take it for life - and yes it makes sense to combine it with a healthier lifestyle and more exercise, knowing the people concerned I don't think that's happening YET. Maybe as it gets easier to move around ...

I'm still surprised it is so widespread and I never heard of it before! laugh
I know someone who used it and lost forty pounds...her mother tried it..but, she could not tolerate the severe nausea from it...and stopped using it.

The problem is that many are using it to lose just 10 to 15 pounds...which it is not meant to be used for..

That is part of the problem with the shortage for the people who really need it.

It is also very expensive here...
Obesity is strange. During long term illness the obese tend to survive.
I think the range is morbidly obese and super thin have roughly the same death rates. Everyone else is at far lesser risk.


The Obesity Paradox: How Fat Can Be Good for You

Despite having a bad reputation in the wellness world, body fat is important for your health, too.

...
Fat people are less likely to die from certain conditions

One of the main reasons that doctors discourage fatness is because higher BMIs are associated with a greater risk of chronic conditions like diabetes, heart disease and heart failure. But there's another important piece of the puzzle. Studies consistently find that overweight or obese individuals with these conditions are less likely to die from them than normal or underweight people, a sign that a high BMI offers some sort of protective effect -- another example of the obesity paradox.

As we age, being "moderately overweight" also seems to offer protection against developing multiple comorbid diseases, making it a "marker of a healthy aging process," according to a 2019 study in Italy. That's in line with Flegal's findings that overweight people live longer.

More fat = more muscle

Bigger people tend to be stronger than thin people, according to research, making them better at strength exercises such as weight lifting. That's because, in addition to having more fat tissue, they have more muscle mass, too. This is true for fat people of all ages, from youth to old age.
Fat offers protection from injuries

Having a higher BMI also offers protection from injury in some cases. A 2020 study found that overweight and class I obese trauma patients had better chances of survival than patients with a "normal" BMI. In the past, researchers have also found that subcutaneous fat may help protect from injuries in car crashes in particular, and that overweight people had less severe injuries in a crash than thin people, though the research is mixed on this matter.
Fatness and fitness

It's clear that fat isn't the enemy, and can even be a perk in some cases. But bottom line: There's no need to be thinner or fatter in order to be healthy. You can be healthy at any size, while the reverse is also true: one study found that almost half of "overweight" people were metabolically healthy, while 30% of "normal" people were not.

Various studies have found that physical activity seems to matter more for health than BMI. In one 2017 study in the Netherlands, for example, people with high BMIs who were very physically active had the same likelihood of heart disease as people with normal BMIs who were just as active.

Correlation doesn't equal causation. It's possible that the link between obesity and certain diseases has some other underlying reason. Rather than obesity causing disease, perhaps the two share a common, third cause, such as societal factors or diet. Weight stigma could also play a mediating role in predisposing fat people to illness.

Centuries ago, having visible body fat was considered healthy; plumpness was the aspirational beauty standard, not thinness, as detailed in Sabrina Strings' book Fearing the Black Body: The Racial Origins of Fat Phobia. Not only do beauty and health values fluctuate over time, but the very definitions of fatness and thinness are moving goalposts. It's not surprising that being technically "overweight" or "obese" doesn't consistently translate to poorer health, and that yes, body fat has its benefits.
Plus keeps you warm
Found it
Claus von Bülow

n 1982, Bülow was arrested and tried for the attempted murders of Sunny on two occasions in two consecutive years. The main medical and scientific evidence against him was that Sunny had low blood sugar, common in many conditions, but a blood test showed a high insulin level. The test was not repeated. A needle was used as evidence against Bülow in court, with the prosecution alleging that he had used it and a vial of insulin to try to kill his wife. His mistress of two years, the soap opera actress Alexandra Isles, testified "He said that they had been having a long argument, talk, about divorce that had gone on late into the night. She had drunk a great deal of egg nog. And then he said, ‘I saw her take the Seconal.’ And then he said that the next day when she was unconscious that he watched her knowing that she was in a bad way, all day, and watched her and watched her. And finally, when she was at the point of dying he said that he couldn’t go through with it and he called (the doctor) and saved her life. The discovery of these items became the focal point of Bülow's appeal.

At the trial in Newport, Rhode Island, Bülow was found guilty and sentenced to 30 years in prison; he appealed, hiring Harvard Law School professor Alan Dershowitz to represent him. Dershowitz served as a consultant to the defense team led by Thomas Puccio, a former federal prosecutor. Dershowitz's campaign to acquit Bülow was assisted by Jim Cramer and future New York attorney general and governor Eliot Spitzer, who were then Harvard Law School students. Dershowitz and his team focused on the discovery of the bag containing the syringes and insulin. Sunny's family had hired a private investigator to look into her coma. The private investigator, Edwin Lambert (an associate of the Bülows' lawyer Richard Kuh), was told by several family members and a maid that Claus had recently been seen locking a closet in the Newport home that previously was always kept open. The family hired a locksmith to drive to the mansion, with the intention of picking the closet lock to find what the closet contained. They had lied to the locksmith and told him that one of them owned the house. When the three arrived, the locksmith insisted that they try again to find the key, and after some searching, Kuh found a key in Claus von Bülow's desk that unlocked the closet. At this point, according to the three men in the original interviews, the locksmith was paid for the trip and left before the closet was actually opened, although the men would later recant that version and insist that the locksmith was present when they entered the closet. It was in the closet that the main evidence against Claus von Bülow was found. In 1984, the two convictions from the first trial were reversed by the Rhode Island Supreme Court. In 1985, after a second trial, Bülow was found not guilty on all charges.

At the second trial, the defense called eight medical experts, all university professors, who testified that Sunny's two comas had not been caused by insulin, but by a combination of ingested (not injected) drugs, alcohol, and chronic health conditions. The experts were John Caronna (chairman of neurology, Cornell); Leo Dal Cortivo (former president, U.S. Toxicology Association); Ralph DeFronzo (medicine, Yale University); Kurt Dubowski (forensic pathology, University of Oklahoma); Daniel Foster (medicine, University of Texas Southwestern); Daniel Furst (medicine, University of Iowa); Harold Lebovitz (director of clinical research, State University of New York); Vincent Marks (clinical biochemistry, Surrey, vice-president Royal College of Pathologists and president, Association of Clinical Biochemistry); and Arthur Rubinstein (medicine, University of Chicago).
Cortivo testified that the hypodermic needle tainted with insulin on the outside (but not inside) would have been dipped in insulin but not injected; injecting it through flesh would have wiped it clean. Evidence also showed that Sunny's hospital admission three weeks before her final coma showed she had ingested at least 73 aspirin tablets, a quantity that could only have been self-administered, and which indicated her state of mind.

Dershowitz, in his book Taking the Stand, writes about Claus von Bülow's dinner party after he was found not guilty at his trial. Dershowitz replied to the invitation that he would not attend if it was a "victory party," and Bülow assured him that it was only a dinner for "several interesting friends." Norman Mailer also attended the dinner where Dershowitz explained why the evidence pointed to Bülow not having attempted to murder his wife. As Dershowitz recounted, Mailer grabbed the arm of his wife, Norris Church Mailer, and said: "Let's get out of here. I think this guy is innocent. I thought we were going to be having dinner with a man who actually tried to kill his wife. This is boring."

Upon his acquittal, von Bülow made his home in London while making occasional appearances at social events and Broadway opening nights in London for the rest of his life.
I wouldn't recommend to anyone who isn't diabetic to use Ozempic and similar drugs for weight loss.
I have seen the result and the look isn't flattering.
First, there are many side effects that can cause serious problems especially if drug is taken longer.

"Nausea, vomiting, diarrhea, abdominal pain and constipation.
Pancreatitis, hypoglycemia, gallbladder problems, allergic reaction, kidney failure, changes in vision.
Thyroid C-cell tumors, medullary thyroid carcinoma (MTC)"

Terrible skin laxity is very common and should not be overlooked too.


One of the best way to lose weight without being on a diet is the Food combining.
And to prevent the insulin spiking, you can just follow a simple rule when eating.
Green leafed veggies first, meat second, slow carbohydrates such as pasta and bread third and last come the sugars. You don't even need to wait in between.


bouquet
Many years ago the actress from taxi stated to never mix foods. Like carbs and proteins.
Joe Rogan and Pavel Tsatsouline discussing nutrition. It is honest.
My daughter is co-owner of a local fitness center.

She has clients who are using it...She also sees the grayish color in their skin from using it...

She would never recommend using it.
Bloody hell, I'll copy-paste your reply to her, thanks wow
And pass on the diet suggestion from both of you handshake
He's frankly grayish anyway, but not the daughter, something to watch for. This is literally scary stuff. help
The Rogan Pavel thing was pretty honest regarding biological differences and nutrition.
Many years ago there was a mega vitamin book.
In the back was some case studies.
One was Clint Eastwood.
All the mega vitamin people recommend a complete blood panel to identify what is lacking.
I often wonder why doctors never request a DNA test to identify p[possible future issues.
8 billion people and each has a specific Biology.
One size does not fit all.



teddybear
I'm a type two diabetic and I'm on Metformin (2000mg/day) and Ozempic (1mg/week). I have recently lost 80 lbs and can contribute some of it to Ozempic. But I have also dieted and exercised too. A combination of all has led me to where I am now. I still have 40 lbs to go. My A1C has gone from 7.8 to 6.1, which is almost normal.

Ozempic can be a good way to lose weight, but under a doctor's supervision is recommended. I've had no side effects and a friend who recently taken it has no side effects either. Anecdotal evidence but like I said, be careful and don't rely on the medicine alone to lose weight.
We learn something new every day laugh

This insulin was on my news channel

I saw great results These woman only injected the insulin for six months

They saw results they were motivated to become active & this insulin helped them to understand portions on their plates which also helped them to eat healthy as well as being able to have their favourite slice of cake & so on

They didn't look grey in fact they glowed & I can't imagine a doctor here allowing a person whom isn't a diabetic to take this insulin for life all for the sake of losing & keeping weight off

Same goes for those who try pill or any fad diet for that matter once you stop you gain it all back again

Thing is these woman changed their lifestyle & they looked fab
Whoops, realized I hadn't responded to this and I had wanted to. Not just centuries ago - to be well-fleshed but healthy after middle age is a sign of success in life, not only the countries where others are starving. Morbid obesity is obviously unhealthy, skeletal is horrendous. I'm over my 'proper' weight and not too fussed about it - on the plus side, fewer wrinkles grin and so long as shops continue to stock the L sizes (ok some brands XL uh oh) who cares? No-one who matters. snooty

However in this case the dad is morbidly obese, has a heart condition, and increasing problems with his knees and back so losing blubber is definitely going to improve his general health. Daughter was spurred into action by now having to buy clothes on plus-size websites. Maybe it comes down to balancing risk and the jury still seems out on that on this blog. I'm personally more convinced than at the start that I won't be trying it but I'm not as astonished as I was that they are.

dancing elephant
Wow what a success story handshake well done YOU. Just out of interest, is the friend diabetic, or only using Ozempic for weight control?
I completely agree that lifestyle changes are key, and reap the benefits. I did think at the start that they were going to rely on insulin to do all the work while they stuck to their usual habits - almost using it as an appetite suppressant only. Hopefully not!

Tell you what, though, don't think many could match your discipline and exercise regime applause
I can't address the weight loss but Taichi and Qigong have been proven to alleviate the back and knee problems
You can Youtbe sitting Qigong, pretty simple movement and breathing..
Being fat was a sign of wealth. Remember the term fat and happy?
Suntan, sign of poverty, thin sign of poverty, wearing jeans, sign of poverty.
Pale sign of wealth. I mentioned fat already.

teddybear
People forget about WATER.
Most piping is very old internal home and external supply from pumping site.
Way back when they used Lead to seal the pipes. That takes about fifty years to start breaking down.
You can purchase water filters that mainly remove sediment.
You can pay for the more expensive ones that use something like three gallons of water to produce one.
Many people do.
You can distill your won water and store it preferably in glass but a non bap plastic works.
Purchased water is usually tap water in the US.
Bottler water is distilled water with the minerals added back in.
Have your water tested and use whatever means are at your disposal to have healthier water to drink.
With weight loss, rapid weight loss, the body fat stores many chemicals and nasty things from food and water.
Rapid weight loss will release those into the system creating even more problems.
Sadly most doctors ignore that as a factor in healthy weight loss.
Basically they medicate for what they THINK is going on.

teddybear
She's using it for weight control. So far so good as she has lost 13 lbs (about a stone) in three weeks.
Corpses always lose weight.

Insulin is one of the deadliest poisons known.

If you take too much you run the real risk of having your blood sugar drop below the level needed to keep your always hungry brain cells alive. Seizures, collapse and stroke and death can soon follow. Call it a consumer choice if they intake it for fun.

At the same time, the more of it in your blood, the less tolerant of it your cells become and insulin rejection becomes a possibility with more and more insulin needed to reduce the blood sugars. This why Diabetes is classified as a progressive disease. Diabetics who do nothing to change their diet and life style will begin to need larger and larger insulin doses as the years progress. But the risk of an overdose also grows and death can result.
Latest update is that the father has had to stop because he was feeling so very ill. He lost 8 kgs (around 18 lbs?) in the 3 weeks and still doesn't have normal appetite back, so will likely lose a bit more especially if he can keep his portions to the new lower level. The daughter has no appetite whatsoever and is having to force herself to eat, but has only lost 4 kgs. She's not feeling ill per se but obviously not feeling well generally due to lack of proper food intake. As for exercise ... he doesn't have the energy for it and she's too weak to persist in the little she tried. So you'd have to say not a success story yet. I suspect even the tiny doses they are apparently on aren't tiny enough.

Scary stuff, Ken, thanks for the input.
I'm diabetic, since the beginning of the year, my doctor wanted to prescribe this for me, but sad to say, no matter which product name is being sold by, it's all sold out. I read somewhere that some time along the way, it will/could have negative effects for those who are not diabetic, but use it for weight loss.

I find it very egoistic of those who are not diabetic and using it as a "mode for weight loss", denying us diabetics who (it was developed for) will profit more from it. It will not only help us to lose weight, but also help our own insulin production/ distribution.
That sucks bigtime, hope you get sorted soon. wow
Thanks @ Suziecute: I've started going to the gym again, so soon I'll loose the 20kg, I want to loose.
Gigi64 wrote : I find it very egoistic of those who are not diabetic and using it as a "mode for weight loss", denying us diabetics who (it was developed for) will profit more from it.

thumbs up thumbs up
I have Diabetes2,and am on 1000mg/day Metformin!
I take a dim view that some new Fad will eventually push the price of my Medication upwards,and even worse,the price of Insulin going to astronomic heights for sufferers of Diabetes I,whose very Life depends on Insulin.
Its said that Stalin might have been taken out in that manner!
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suziecute

suziecute

Salobreña, Andalusia, Spain

Stranger in a strange country - learning Spanish, not very good at it but I'm trying. Yes, I know, very.

I'm usually cheerful and look, I'm on a dating site, optimistic is a given. Can't cook very well. I'm a good listener, guaranteed to [read more]

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